Human Cancer Biology Conjunctival Melanomas Harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas
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چکیده
Purpose:Conjunctivalmelanoma is a rare but potentially deadly tumor of the eye. Despite effective local therapies, recurrence and metastasis remain frequent. Once the tumor has metastasized, treatment options are limited and the prognosis is poor. To date, little is known of the genetic alterations in conjunctival
منابع مشابه
Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.
PURPOSE Conjunctival melanoma is a rare but potentially deadly tumor of the eye. Despite effective local therapies, recurrence and metastasis remain frequent. Once the tumor has metastasized, treatment options are limited and the prognosis is poor. To date, little is known of the genetic alterations in conjunctival melanomas. EXPERIMENTAL DESIGN We conducted genetic analysis of 78 conjunctiva...
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متن کاملConjunctival melanomas harbor BRAF and NRAS mutations--Letter.
tions and similarities in chromosomal gains and losses (1). Specifically, 27% of 78 primary or locally recurrent conjunctival melanoma samples harbored a BRAF V600E mutation. Another study also demonstrated BRAF V600E mutations in 58% of conjunctival melanomas (primary and metastatic) (2). The incidence of this mutation approximates that reported in cutaneous melanoma (3). Now that two phase II...
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BACKGROUND Malignant melanoma arising from different body compartments may be associated with differing aetiological factors and clinical behaviour, and may manifest diverse molecular genetic profiles. Although many studies have focused on cutaneous melanoma, little is known of mucosal and other types of melanoma. In particular, malignant melanoma of soft parts is different from other melanomas...
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